The limiting effect of the human visual system on image processing

With the application of linear systems analysis, Fourier theory, and signal processing theory to vision science, the properties of the visual system are being defined in terms of such things as the modulation transfer function CMTF) . Earlier experimentation by other researchers has calculated the visual MTF using simple sine-wave targets. This experiment demonstrates the correlation between the visual MTF and the frequency content of simple images. The effect of image contrast is also shown to have an effect on the subjective evaluation of image sharpness. This experiment shows the need to consider the characteristics of the human visual system when digitally processed images are to be viewed

A Visual Programming Language for Data Flow Systems

The concept of visual programming languages is described and some necessary terms are defined. The value of visual languages is presented and a number of different visual languages are described. Various issues, such as user interface design, are discussed. As an example of a visual programming language, a graphical data flow programming environment is developed for the Macintosh workstation which functions as a preprocessor to a data flow simulator developed at RIT. Examples are presented demonstrating the use of the language environment. Issues related to the development of the programming environment are described and conclusions regarding the development of visual programming languages in general are presented

MFIRE-2: A Multi Agent System for Flow-based Intrusion Detection Using Stochastic Search

Detecting attacks targeted against military and commercial computer networks is a crucial element in the domain of cyberwarfare. The traditional method of signature-based intrusion detection is a primary mechanism to alert administrators to malicious activity. However, signature-based methods are not capable of detecting new or novel attacks. This research continues the development of a novel simulated, multiagent, flow-based intrusion detection system called MFIRE. Agents in the network are trained to recognize common attacks, and they share data with other agents to improve the overall effectiveness of the system. A Support Vector Machine (SVM) is the primary classifier with which agents determine an attack is occurring. Agents are prompted to move to different locations within the network to find better vantage points, and two methods for achieving this are developed. One uses a centralized reputation-based model, and the other uses a decentralized model optimized with stochastic search. The latter is tested for basic functionality. The reputation model is extensively tested in two configurations and results show that it is significantly superior to a system with non-moving agents. The resulting system, MFIRE-2, demonstrates exciting new network defense capabilities, and should be considered for implementation in future cyberwarfare applications

Identification of a non-mammalian leptin-like gene:characterization and expression in the tiger salamander (Ambystoma tigrinum)

Leptin is well established as a multifunctional cytokine in mammals. However, little is known about the evolution of the leptin gene in other vertebrates. A recently published set of ESTs from the tiger salamander (Ambystoma tigrinum) contains a sequence sharing 56% nucleotide sequence identity with the human leptin cDNA. To confirm that the EST is naturally expressed in the salamander, a 409 bp cDNA was amplified by RT-PCR of salamander testis and stomach mRNAs. The coding sequence of the cDNA is predicted to encode 169 amino acids, and the mature peptide to consist of 146 residues, as in mammals. Although the overall amino acid identity with mammalian leptins is only 29%, the salamander and mammalian peptides share common structural features. An intron was identified between coding exons providing evidence that the sequence is present in the salamander genome. Phylogenetic analysis showed a rate of molecular divergence consistent with the accepted view of vertebrate evolution. The pattern of tissue expression of the leptin-like cDNA differed between metamorphosed adult individuals of different sizes suggesting possible developmental regulation. Expression was most prominent in the skin and testis, but was also detected in tissues in which leptin mRNA is present in mammals, including the fat body, stomach, and muscle. The characterization of a salamander leptin-like gene provides a basis for understanding how the structure and functions of leptin have altered during the evolution of tetrapod vertebrates

A matrix isolation and computational study of molecular palladium fluorides : does PdF₆ exist?

Palladium atoms generated by thermal evaporation and laser ablation were reacted with and trapped in F₂ /Ar, F₂ /Ne, and neat F₂ matrices. The products were characterized by electronic absorption and infrared spectroscopy, together with relativistic density functional theory calculations as well as coupled cluster calculations. Vibrational modes at 540 and 617 cm⁻¹ in argon matrices were assigned to molecular PdF and PdF₂ , and a band at 692 cm⁻¹ was assigned to molecular PdF₄ . A band at 624 cm⁻¹ can be assigned to either PdF₃ or PdF₆, with the former preferred from experimental considerations. Although calculations might support the latter assignment, our conclusion is that in these detailed experiments there is no convincing evidence for PdF₆

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum

Ero1 is thought to be the only oxidase that mediates the re-oxidation of protein disulphide isomerases (PDIs) during oxidative protein folding in the ER. This study reveals that peroxiredoxin IV can also directly oxidize PDI-family members and thus act as a second source of oxidizing equivalents for disulphide-bond formation in the ER

Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(IV) prodrugs

A series of Pt(IV) prodrugs has been obtained by oxidative halogenation of either cisplatin or carboplatin. Iodobenzene dichloride is a general reagent that cleanly provides prodrugs bearing axial chlorides without the need to prepare intervening Pt(IV) intermediates or handle chlorine gas. Elemental bromine and iodine afford Pt(IV) compounds as well, although in the case of the iodine-mediated oxidation of carboplatin, an amido-bridged Pt(IV) side product also formed. A detailed analysis of the changes in spectroscopic and structural parameters induced by varying the axial halide is presented. A number of recurring motifs are observed in the solid state structures of these compounds.National Cancer Institute (U.S.) (Grant CA034992

Electrochemical Solutions for Advanced Life Support

The Oxygen Generating Assembly (OGA) on-board the International Space Station (ISS) employs a polymer electrolyte membrane (PEM) water electrolysis cell stack to electrochemically dissociate water into its two components oxygen and hydrogen. Oxygen is provided to the cabin atmosphere for crew respiration while the hydrogen is delivered to a carbon dioxide reduction system to recover oxygen as water. The design of the OGA evolved over a number of years to arrive at the system solution that is currently operational on ISS. Future manned missions to space will require advanced technologies that eliminate the need for resupply from earth and feature in-situ resource utilization to sustain crew life and to provide useful materials to the crew. The architects planning such missions should consider all potential solutions at their disposal to arrive at an optimal vehicle solution that minimizes crew maintenance time, launch weight, installed volume and energy consumption demands. Skyre is developing new technologies through funding from NASA, the Department of Energy, and internal investment based on PEM technology that could become an integral part of these new vehicle solutions. At varying stages of Technology Readiness Level (TRL) are: an oxygen concentrator and compressor that can separate oxygen from an air stream and provide an enriched oxygen resource for crew medical use and space suit recharge without any moving parts in the pure oxygen stream; a regenerative carbon dioxide removal system featuring a PEM-based sorbent regenerator; a carbon dioxide reduction system that electrochemically produces organic compounds that could serve as fuels or as a useful intermediary to more beneficial compounds; and an electrochemical hydrogen separator and compressor for hydrogen recycle. The technical maturity of these projects is presented along with pertinent performance test data that could be beneficial in future study efforts